Starting YOUR Treatment Journey?
Explore support and resources as you get started with treatment.
Your Resources
Starting a new treatment is a big step. View or download the resources below for support along the way
Use this tool to help you and your healthcare provider have productive conversations about your narcolepsy and sleep patterns
You are never alone on your LUMRYZ treatment journey
Explore each role played in supporting your treatment experience
RYZUP Support Services Nurse Care Navigator (NCN)
Connects you to support and educational resources you may need at every step of your treatment journey.
Healthcare Provider
Partners with you to create your treatment plan and answers your medical questions.
Specialty Pharmacy
Arranges your shipments of LUMRYZ after your prescription is processed and answers product-related questions.
Your NCN will help you access, start, and stay on track with your LUMRYZ treatment plan.
Available to help you prepare for check-ins with your healthcare team
Will help you navigate the insurance process and any changes to your insurance
Can initiate a 3-way phone call with your specialty pharmacy to start the conversation about arranging your next shipment
Refer to this guide as a reminder of the support offerings available.
Your NCN is here to help you start on LUMRYZ
Coverage
Your NCN will work with your healthcare provider and insurance provider to help determine coverage and your out-of-pocket costs.
Financial Assistance
Your NCN will help connect you with financial assistance, if you qualify.
Approval
Your NCN will provide support to your healthcare provider as they work with your insurance provider to obtain coverage approval.
Delivery
Once this process is complete, your specialty pharmacy will call to schedule your first prescription shipment. Be sure to return any missed calls from them promptly.
Avadel Pharmaceuticals is committed to helping patients access, start, and stay on track with their LUMRYZ treatment plan. That’s why we offer support services to help in navigating access to LUMRYZ and provide financial assistance programs to those who qualify.
Your NCN will check in regularly via phone and email—they are also available if you have questions or feel unsure about next steps. You can reach your NCN at 1-844-485-7636 from 8:00 AM to 8:00 PM Eastern Time, Monday through Friday.
Tyler’s experience working with HIS NCN
“Insurance and co-pays and prior authorizations are extremely confusing for me, especially because I’m a college student and take care of things like health insurance by myself.
RYZUP Support Services has been great at guiding me through that process. They also make sure that I get ahead of when I need my medicine and that my delivery is scheduled.”
—Tyler F., living with narcolepsy and treating with LUMRYZ
Tyler was compensated by Avadel Pharmaceuticals for his time. Individual results may vary.
Ready to start taking your LUMRYZ dose?
LUMRYZ contains a unique extended-release formulation. What this may mean as you prepare, shake, and take* LUMRYZ:
Mixing
Your dose will not fully dissolve in water, even after shaking thoroughly in the mixing cup.
Texture
Because your dose will not fully dissolve, the texture may appear gritty and slightly milky with some granules that stick together even when fully mixed.
Taste
Your dose has a salty taste.
Residue
Make sure to take your full dose. After drinking, immediately fill the mixing cup to line B with water, shake for 10 seconds, and drink the rest. There may be residue around the cup after you take your dose.
Empty any unused LUMRYZ down the sink drain the next day. Clean the mixing cup by rinsing it with water and letting it dry before each use.
*These instructions are not complete. Please see Instructions for Use for complete administration directions.
About your LUMRYZ sodium oxybate
The active ingredient of LUMRYZ is sodium oxybate. While the exact way sodium oxybate works is unknown, it’s thought to affect the parts of your brain linked to symptoms of excessive daytime sleepiness (EDS) and cataplexy—all while you sleep.
See how LUMRYZ fits into your bedtime routine
Want a dosing guide for your bedside? Save this brochure to have handy as you prepare your dose.
Katie’s bedtime routine
“I like to use my bedtime routine to wind down after my day. I read something just for fun, brush my teeth and wash my face. Once I’m in bed, I prep and take my LUMRYZ dose, then think about what I’m going to do the next day as I fall asleep.”
—Katie L., living with narcolepsy and treating with LUMRYZ
Katie was compensated by Avadel Pharmaceuticals for her time. Individual results may vary.
Frequently Asked Questions
Select a question below to see the answer
If you are ever unclear on next steps with insurance and benefits investigation, finding financial assistance, prescription shipments, or other questions about starting LUMRYZ, you can call your NCN for support.
No, you can remain on your twice-nightly oxybate until the insurance coverage process for your LUMRYZ prescription is complete.
If there is a delay in insurance coverage, you may be eligible for up to 120 days of free LUMRYZ with the Temporary Assistance Program.†
†Applies only to eligible, commercially insured patients.
Your dedicated NCN will help connect you with any financial assistance you may qualify for, including:
Your co-pay could be as little as $0 if you have commercial insurance.‡
Temporary Access Program (TAP) If there is a delay in insurance coverage, you may be eligible for up to 120 days of free LUMRYZ.§
Patient Assistance Program (PAP) Treatment is available free of charge to eligible patients who are uninsured or underinsured.||
You can ask your NCN about available support services at any time during your treatment experience.
‡This offer is valid only for patients who have commercial insurance. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Additional terms and conditions apply. Download the full terms and conditions of the co-pay program.
§Applies only to eligible, commercially insured patients.
||PAP application required. Patient must meet certain financial and other criteria.
With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the full Instructions for Use for how to prepare, shake, and take LUMRYZ.
Watch this video for a step-by-step guide or download the LUMRYZ Dosing Guide for an offline resource.
After following the full Instructions for Use to prepare your LUMRYZ dose, you may notice the mixture does not fully dissolve in water and has a gritty texture with a salty taste.
This is because the unique formulation is designed to release medicine into the body while you sleep—which is what makes LUMRYZ a once-at-bedtime oxybate treatment.
Titration is the process of allowing the body to adjust to a new medicine by starting with the smallest dose—then going up a dose, slowly over time, and possibly going back down a dose to try and find a stable dose that balances effectiveness and tolerability. It may take 3 to 13 weeks for this to occur.
It’s important to share all of your treatment experiences with your healthcare provider during the titration process so you can work together to find the best treatment fit for you.
Everyone responds to treatment differently. In the clinical trial for LUMRYZ, some participants saw significant symptom improvements as early as week 3 while others saw symptom improvements at week 13¶ after titrating to a higher dose.
Consider keeping track of how you are feeling with LUMRYZ in a symptom journal.
¶The LUMRYZ double-blind, placebo-controlled clinical trial included participants with narcolepsy treated with LUMRYZ (n=107). The results measured at week 3 (n=88), week 8 (n=77), and week 13 (n=69) showed daytime symptom improvement of participants on the 6-g, 7.5-g, and 9-g doses of LUMRYZ, respectively. Individual results may vary.
In a clinical trial, the total sleep time did not change from when the trial started to the end of the trial. LUMRYZ participants slept for approximately 7 hours at the beginning and end of the trial.
People with narcolepsy generally sleep the same amount of time at night as people without narcolepsy, but most people with narcolepsy don’t have good quality sleep. Speak to your healthcare provider about your sleep as well as how you feel when you wake up the following day.
The most common side effects reported by adult participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.
In the clinical trial for LUMRYZ, side effects typically occurred when participants started a new dose. Generally, the side effects then declined over time while staying on the same dose.
The safety of LUMRYZ for the treatment of cataplexy or excessive daytime sleepiness in pediatric patients 7 years of age and older with narcolepsy was determined in a well-controlled trial of immediate-release sodium oxybate.
The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.
Explore the side effects over time in the clinical trial for LUMRYZ.
