Get ready for your LUMRYZ journey

Once your healthcare provider prescribes LUMRYZ, it's helpful to have a clear picture of what steps should come next. This timeline provides an overview of the typical stages of your journey with LUMRYZ.

Download Timeline PDF

Finding your stable dose

Titration is a process that may take time

Titration is the process of allowing the body to adjust to a new medicine by starting with the smallest dose—then going up a dose, slowly over time, and possibly going back down a dose to try and find a stable dose that balances effectiveness and tolerability.

Because everyone's titration experience is different, it's important to take LUMRYZ exactly as your healthcare provider prescribes. Sharing changes in symptoms or tolerability with your healthcare provider throughout your treatment can help inform your titration process and help you find your stable dose.

Your stable dose will be the dose that balances your efficacy and tolerability.

It’s okay to need extra support during your treatment with LUMRYZ

If you have questions about how to prepare, shake, and take your LUMRYZ dose, you can contact your Nurse Care Navigator (NCN).

MELANIE DISCUSSES HER SIDE EFFECTS

"I informed my healthcare team as soon as I started experiencing side effects. I discussed my symptoms and how I was feeling. My healthcare team and I decided to adjust my treatment plan with this information. It's so important to stay in contact with your healthcare team, especially when you start a new treatment.”

— Melanie W., living with narcolepsy and treating with LUMRYZ

Melanie was compensated by Avadel Pharmaceuticals for her time. Individual results may vary.

Listen to your body as you titrate

You and your healthcare provider will work together to make adjustments to your dose based on how you are responding to treatment

Tip: Ask your healthcare provider what information would be helpful for you to share during your titration process.

The most common side effects reported by adult participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

In pediatric patients, the most common side effects include nausea, bedwetting, vomiting, headache, weight decreased, decreased appetite, dizziness, and sleepwalking.

During the titration process, it's important to discuss how you're feeling with your healthcare provider since they can work with you to adjust your treatment plan if needed. You can also reach out to your NCN for help preparing for your next appointment.

Understanding the safety data of LUMRYZ in adults

In the clinical trial, side effects typically occurred when participants started a new dose. Generally, the side effects then declined over time while staying on the same dose.

Use the chart below to explore how the frequency of side effects changed in the clinical trial

Notice the change in the bars from week to week when titrating.

SIDE EFFECTS OF LUMRYZ OVER TIME

4.5 g 6 g 7.5 g 9 g Week 1 Patients, % Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 0 1 2 3 4 5 6 7 8 9 10 4.5 g 6 g 7.5 g 9 g W1 W2 W3 W4 W5 W6 W7 W8 W9 W10 W11 W12 W13 Patients, % 0 1 2 3 4 5 6 7 8 9 10
  • Nausea
  • Vomiting
  • Decreased appetite
  • Headache
  • Dizziness
  • Bedwetting
  • Anxiety

Participants titrated up a dose every 1-5 weeks for 13 weeks in the clinical trial.

It's important to remember that your titration experience may look different based on what is effective and tolerable for you.

Finding a LUMRYZ dose that works with your treatment goals can take time.

Everyone responds to treatment differently

In the clinical trial, some participants saw improvement in their symptoms by week 3 on a 6-g dose, while others saw improvement at week 13 after increasing the dose to 9 g.*

*The LUMRYZ double-blind, placebo-controlled clinical trial included participants with narcolepsy treated with LUMRYZ (n=107). The results measured at week 3 (n=88), week 8 (n=77), and week 13 (n=69) showed daytime symptom improvement of participants on the 6-g, 7.5-g, and 9-g doses of LUMRYZ, respectively. Individual results may vary.

W, week.

Want to learn more about the LUMRYZ clinical trial?
Download Trial PDF

It may help to keep track of how you’re feeling

As you progress through treatment with LUMRYZ, you'll want to consider how you feel in the morning and throughout the day. It may be helpful to write down your sleep patterns as well.

Keeping a journal can be useful to track how symptoms of excessive daytime sleepiness (EDS) and/or cataplexy may change.

Throughout your treatment, it's important to tell your healthcare provider about any side effects you experience. They may choose to make adjustments to your dose or stop treatment.

Use this tool to take notes about your sleep for discussion with your healthcare provider.

Download Sleep Tracker

You are not alone at any step with LUMRYZ

Your NCN team is a phone call away

You can contact your NCN to help you prepare for discussions with your healthcare provider, such as writing down helpful notes to bring to your next treatment check-in.

RYZUP™ Support Services can connect you with your NCN: 1-844-485-7636.

Everyone's treatment experience is different

Explore these words of inspiration from healthcare providers who prescribe LUMRYZ and a person with narcolepsy

Individuals featured have been compensated by Avadel Pharmaceuticals. Individual results may vary.

“When I explain titration to my patients, I like to describe it as: During the titration process, your dose may be adjusted based on what is effective and tolerable for you. It may take time to notice a difference in your symptoms of EDS or cataplexy.

For some people, adjusting to a new medicine and treatment routine may be challenging—and that’s why I am here to help. Consider writing down your experiences each week so we can discuss them during check-ins.”

“When I switched from my twice-nightly oxybate to LUMRYZ, the titration process wasn’t as challenging as I had expected (perhaps because I didn’t know what to expect). I started on the LUMRYZ dose closest to what twice-nightly oxybate I was taking and shared with my doctor how I was feeling and what symptoms I was experiencing. After a few weeks, my doctor then increased my dose and we again discussed how my EDS and cataplexy symptoms were and if I was experiencing any side effects. My doctor adjusted my LUMRYZ dose once and that is the dose I am taking today.”

“I typically ask my patients to check in with me after 3 weeks. I ask them how they’re feeling when they wake up and throughout the day, and what impact they may start to notice in their symptoms.

Sometimes, we may keep them on the same dose for longer before changing anything—or we may titrate them up or down to a different dose. It is important for patients who start on a 4.5-g dose to know that it may not be their stable dose based on effectiveness and tolerability.

It’s common for patients to experience side effects after titrating to a different dose, which is why I like to check in with my patients about how they’re feeling during the process. And sometimes, it may not be the right treatment.

But overall, the best advice I can give is have patience. Treating narcolepsy isn’t a sprint, it’s a marathon.”